Basic Information
VIS ID
TVIS20002797
Fusion event
HPV-MEI1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
42168483/41772479 (Hg38)
End
42168483/41772479 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
MEI1
miRNAs that regulate target gene
hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6818-3p ; hsa-mir-4314 ; hsa-mir-6873-3p ; hsa-mir-4436b-5p ; hsa-mir-2861 ; hsa-mir-378g ; hsa-mir-4486 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6845-3p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-6758-3p
Nearest miRNA
hsa-mir-1281/Upstream/519429; hsa-let-7a-3/Downstream/128465;
Nearest TSS
ENST00000624155/Upstream/18896; ENST00000473736/Downstream/1701;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/72294, chr22-CpG: 76/Downstream/27470
Upstream sequence
tgcctataatcccagtactttgggaggccgagccaggtgaatcacctgaggtcaggagttcaagaccaagtagctggaactacaagcatgtgctactgtg
Downstream sequence
tctggctaatttttatattttttgtagagacagtgttttatcatgttgcccaagctggtctcaaattcctgggctccagcgatcctcccaccatggcctc
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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