Basic Information
VIS ID
TVIS20002798
Fusion event
HPV-chr22:q13.2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
43806022/43410016 (Hg38)
End
43806022/43410016 (Hg38)
Fragile sites / regions
FRA22A
Nearest miRNA
hsa-mir-1281/Upstream/1486719; hsa-let-7a-3/Downstream/1790938;
Nearest TSS
ENST00000624155/Upstream/9685; ENST00000465861/Downstream/1180;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/65737, chr22-CpG: 112/Downstream/1378
Nearby gene
LINC01639(-335) ; MPPED1(+1998) ;
Upstream sequence
TGAGGGCTACATAAGACAGTGTGGGTCAAGCTGAGAGCTCTGCGCCTGGGACTGGGTGGTGCAGGTAGCACCAGGTCCCTCTGGTGGAGAGCTCATGCTT
Downstream sequence
GGCTTCAAAGCAAGTGCCGAGTGCCAGGAATATGGTAGATGCTCAATAAATGTGTACCCTGGGAAGGTAAGAGATGATGCTCTGGGACTTGAGGGTAGTT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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