Basic Information
VIS ID
TVIS20002799
Fusion event
HPV-SLC6A11 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr3
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
10939522/10897837 (Hg38)
End
10939522/10897837 (Hg38)
Location type
Intronic
Target gene
SLC6A11
Nearest miRNA
hsa-mir-12127/Upstream/503275; hsa-let-7g/Downstream/4598402;
Nearest TSS
ENST00000440867/Upstream/81636; ENST00000464828/Downstream/36129;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/81075, chr3-CpG: 105/Downstream/94720
Upstream sequence
GATTGACCTTTTAAAAGACCTCACTCCACAATTGGATAAGCCCTCTTTTATTTTAAATCATCTTTTGCCACTGGCTTGTGATATCATTTGAAGATGATAT
Downstream sequence
gtctgcactgccttagcagaggttctccataagcaccctgcccctgtagcaaacttctgtctggacatccaggcatttccatacatcttctgaaatctag
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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