Basic Information
VIS ID
TVIS20002805
Fusion event
HPV-WWTR1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr3
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
149349844/149632057 (Hg38)
End
149349844/149632057 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA3D
Target gene
WWTR1
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-18a-5p ; hsa-mir-374a-3p ; hsa-mir-488-3p ; hsa-mir-3148 ; hsa-mir-361-5p ; hsa-mir-4635 ; hsa-mir-873-5p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-5682 ; hsa-mir-200b-5p ; hsa-mir-200a-5p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-101-5p ; hsa-mir-6871-3p ; hsa-mir-29c-3p ; hsa-mir-29b-3p ; hsa-mir-29a-3p ; hsa-mir-3121-3p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-24-3p ; hsa-mir-4746-3p ; hsa-mir-4284 ; hsa-mir-383-3p
Nearest miRNA
hsa-let-7g/Upstream/15194151; hsa-mir-1224/Downstream/1933819;
Nearest TSS
ENST00000440867/Upstream/55805; ENST00000466836/Downstream/24963;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/501876, chr3-CpG: 130/Downstream/24865
Nearest cancer related gene
WWTR1(OG, No orient, 0)
Upstream sequence
cttcatcacatgaagccagctggtgctgcAGCCATCTAGGGcagggctcagcaaactttcccatagaggaccaaataacagatacattaggccttgtgga
Downstream sequence
ccaccactatccacagctaattttttgcatgttttgtagagacagagtctcactatgttgcccaggttggtctcaaactcctgggttcaagcgatctgcc
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate