Basic Information
VIS ID
TVIS20002814
Fusion event
HPV-OXCT1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr5
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
41769474/41769372 (Hg38)
End
41769474/41769372 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
OXCT1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-100-5p
Nearest miRNA
hsa-mir-10397/Upstream/3211811; hsa-mir-103a-1/Downstream/12182132;
Nearest TSS
ENST00000502646/Upstream/29651; ENST00000505931/Downstream/24763;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/258823, chr5-CpG: 104/Downstream/100189
Upstream sequence
gtggtggcacatgcctgtaatctcatctacttgggaggctgaggcaggagaatcacttgaacccaggaggtggaggttgcagtgagccaagaccgcgcca
Downstream sequence
GATTTCTCACATCTGTTCTGATTAATCAGTGCCTGTGCCTTACCACCTAATCAAGACCACCTGTCACAGggccaggtgtggtagctcacacctgtaatct
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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