Basic Information
VIS ID
TVIS20002816
Fusion event
HPV-ACOT12 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr5
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
80631512/81335693 (Hg38)
End
80631512/81335693 (Hg38)
Location type
Intronic
Target gene
ACOT12
miRNAs that regulate target gene
hsa-mir-181a-5p ; hsa-mir-186-5p
Nearest miRNA
hsa-mir-10397/Upstream/8457030; hsa-mir-103a-1/Downstream/1504462;
Nearest TSS
ENST00000502646/Upstream/27025; ENST00000512859/Downstream/209;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/33778, chr5-CpG: 58/Downstream/58120
Upstream sequence
ctctaagttccctcccttcatcccccatcctccaacaggccctggtgtgtgttgatcccctcactgtgtccatgtgttctcaatgttcaactcccactta
Downstream sequence
TGGACTTCAGTATGGAGATCATCTTTTACATTATGTCAAGGTTGATTGAGAAAAATTTTTAAATTTGTTCTTACACAAAATGGGGGTCCCACAAAGGTCG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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