Basic Information
VIS ID
TVIS20002817
Fusion event
HPV-chr5:q14.3 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr5
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
91102630/91806813 (Hg38)
End
91102630/91806813 (Hg38)
Nearest miRNA
hsa-mir-10397/Upstream/1790093; hsa-mir-103a-1/Downstream/1813883;
Nearest TSS
ENST00000502646/Upstream/423454; ENST00000511323/Downstream/275784;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/425700, chr5-CpG: 183/Downstream/1763720
Upstream sequence
ACATATATGTCAATAGTATCCTGAAGAACTGGATGGCGACAAATGGAAGTATACTGCTCTGCTGTATATAAAAACATAAAAGTTAAACACTAAAGCTTCT
Downstream sequence
tatatttttgttttctttttctttttctttttttttctccagacagggtgtctttctatccaggctggagtgtagtggcacaatcatagctcactgcagc
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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