Basic Information
VIS ID
TVIS20002819
Fusion event
HPV-VDAC1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr5
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
133318541/133982850 (Hg38)
End
133318541/133982850 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA5C
Target gene
VDAC1
miRNAs that regulate target gene
hsa-mir-1301-3p ; hsa-mir-320c ; hsa-mir-877-5p ; hsa-mir-744-5p ; hsa-mir-615-3p ; hsa-mir-320a ; hsa-mir-125b-5p ; hsa-mir-10a-5p ; hsa-mir-197-3p ; hsa-mir-106a-5p ; hsa-mir-29a-3p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-93-5p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-17-5p ; hsa-mir-7-5p
Nearest miRNA
hsa-mir-10397/Upstream/555144; hsa-mir-103a-1/Downstream/242907;
Nearest TSS
ENST00000502646/Upstream/1833; ENST00000606089/Downstream/21785;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/14142, chr5-CpG: 216/Downstream/21059
Upstream sequence
ttgttctatcatttaattactttctggcactaatagatccatcagatccatattgtacatttcttcctcaggtctagaatcagctgtttctttaaggatc
Downstream sequence
ctgcactccagcctgggtagcaagaataaaactcagtctcaaaaaaaaaaaaaaaaaTCATGAAacaatcatgtaaatttgaacagactagagatttgac
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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