Basic Information
VIS ID
TVIS20002822
Fusion event
HPV-chr5:q34 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr5
Cytoband
q34
Reference genome
GRCh37/hg19
Start
164889824/165462819 (Hg38)
End
164889824/165462819 (Hg38)
Nearest miRNA
hsa-mir-10397/Upstream/4977369; hsa-mir-103a-1/Downstream/2703026;
Nearest TSS
ENST00000502646/Upstream/113789; ENST00000520075/Downstream/665679;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/1956879, chr5-CpG: 17/Downstream/1515660
Upstream sequence
aatcatctctctctagcttaaagttccacagatctctagggcagggggaaaatgccaccagtctctttgctaatgcatagggtgacttttgctccagttc
Downstream sequence
AAATCAAAACACTAGGGGGGCAGTATTTCTTATGAAAAAATAAACAATGGATGATTAAAAAAATACATAAACTTAATTTCTGCCTCACGATGATGTATGG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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