Basic Information
VIS ID
TVIS20002835
Fusion event
HPV-chr5:q35.2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr5
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
174487338/175060335 (Hg38)
End
174487338/175060335 (Hg38)
Fragile sites / regions
FRA5G
Nearest miRNA
hsa-mir-10397/Upstream/308548; hsa-mir-1229/Downstream/1307611;
Nearest TSS
ENST00000502646/Upstream/64822; ENST00000515791/Downstream/383873;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/308410, chr5-CpG: 145/Downstream/383415
Upstream sequence
GTAGCCAGCTCTCTGCTATAAGATGCATTTCCTTGACAGGATAAAATGTGGAGCCGCATTAGCTGCAAAGTTTACAAAGGTTAGCTAAACACACACAATA
Downstream sequence
ATTTCAAATAAAGCTATCCAGTGGGGCGGGGGAGGGAAGGAAGAGACACAAAATTAACTGTGGCCTCCTCTAGGGAGGATGGCAAGTCCAGGGGAGGGAA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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