Basic Information
VIS ID
TVIS20002837
Fusion event
HPV-MAPK14 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Host Sequence
Chromosome
chr6
Cytoband
p21.31
Reference genome
End
36071084/36103307 (Hg38)
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-1236/Upstream/438518; hsa-mir-10398/Downstream/519129;
Upstream sequence
GGTTCTTCTCTCAAAGTCTACTACTGTTACCATTTTGATATGTTTTCTTCCAGAGGTTTACTCTGCCAGTTAATTAGAATGTAATTGTAATCATATAGTT
Downstream sequence
GTTGCTTTATTATTAttatttatttatttatttatttatttatttTGGTAGTGTcagggtctcgctcttttacccaggctagagtacagtggcacaatca
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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