Basic Information
VIS ID
TVIS20002838
Fusion event
HPV-chr6:p21.2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
38134168/38166392 (Hg38)
End
38134168/38166392 (Hg38)
Fragile sites / regions
FRA6H
Nearest miRNA
hsa-mir-1236/Upstream/610970; hsa-mir-10398/Downstream/907922;
Nearest TSS
ENST00000381078/Upstream/23395; ENST00000412822/Downstream/315300;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/346618, chr6-CpG: 77/Downstream/473037
Nearby gene
BTBD9(+2059) ;
Upstream sequence
aacatagtgttggaagttctggccagggcaatcagtcaggagaaggaaataaagggcattcaattaggagaagaggaagtcaaattgtccctgtttgcag
Downstream sequence
AGCAGAGACCTCCACCTCCCCCCACCCGCACAGCAGAGCCCTCCACCTCCCCCCACCCGCACAGCAGAGCCCTCCACCTCCCCCACGCACAGCAGAGCCC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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