Basic Information
VIS ID
TVIS20002842
Fusion event
HPV-ELMO1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr7
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
37399252/37359649 (Hg38)
End
37399252/37359649 (Hg38)
Location type
Intronic
Target gene
ELMO1
miRNAs that regulate target gene
hsa-mir-6793-3p ; hsa-mir-4267 ; hsa-mir-6736-3p ; hsa-mir-1226-3p ; hsa-mir-548o-3p ; hsa-mir-1323 ; hsa-mir-3591-3p ; hsa-mir-21-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p
Nearest miRNA
hsa-mir-1183/Upstream/440217; hsa-mir-10399/Downstream/5791246;
Nearest TSS
ENST00000635602/Upstream/5981; ENST00000467202/Downstream/89207;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/969452, chr7-CpG: 136/Downstream/88102
Upstream sequence
tcctgggattcccattccctatcatcccagggacacccttttcctctctcctgttttctggaccacaagtcttcctaaatcttggtgtgttgcctgtttg
Downstream sequence
CCATCCGAAGGCAGTGTTCTGAACCATTACCCTAAACTTCCTTGGACCttaatatgcacaaggcttagaacagtgcccggcaccgagtaagagcGTGGCA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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