Basic Information
VIS ID
TVIS20002845
Fusion event
HPV-ANKIB1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr7
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
91986339/92357025 (Hg38)
End
91986339/92357025 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA7E
Target gene
ANKIB1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-335-5p ; hsa-mir-25-3p ; hsa-mir-17-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-3185 ; hsa-mir-5582-3p
Nearest miRNA
hsa-mir-10525/Upstream/152927; hsa-mir-10399/Downstream/1125735;
Nearest TSS
ENST00000635602/Upstream/13887; ENST00000465883/Downstream/14547;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/110488, chr7-CpG: 44/Downstream/90360
Upstream sequence
CCATGGCTAAGGTCCGTTTTCTTCATTATCAGACGCTTGACACTTGGACAGTATTCTTAGATAAACCTCACAGAGAATGCCTTTGTTCACACGGGAGTGC
Downstream sequence
GGATATGAATTTCTTCCATCAAGTAATAAATTTTAAAACTTCAGTGGAAGGTTTTTTCCTTTTCCAGAGCCCTTTAGAACCACTGTATAGTCATGCAGCC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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