Basic Information
VIS ID
TVIS20002848
Fusion event
HPV-PRKAG2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
151373804/151676718 (Hg38)
End
151373804/151676718 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
PRKAG2
Nearest miRNA
hsa-mir-10399/Upstream/243079; hsa-mir-153-2/Downstream/5897618;
Nearest TSS
ENST00000635602/Upstream/43553; ENST00000464464/Downstream/59460;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/43616, chr7-CpG: 33/Downstream/47864
Upstream sequence
ttgtacattgattttgtatcctgagactttgctgaagttgcttatcagcttaaggagattttgggctgagacaatggggttttctagatatacaatcatt
Downstream sequence
GATGTGacctgtgaatgtgaccttatttggaaacagggtcttttcagatcaaccaagtctagatgagattttgctggactagggtgggccctaatgcaat
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate