Basic Information
VIS ID
TVIS20002850
Fusion event
HPV-HNF4G integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr8
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
76457379/75545144 (Hg38)
End
76457379/75545144 (Hg38)
Location type
Intronic
Target gene
HNF4G
miRNAs that regulate target gene
hsa-mir-129-5p ; hsa-mir-3149 ; hsa-mir-576-5p ; hsa-mir-4263 ; hsa-mir-4799-5p ; hsa-mir-30a-5p ; hsa-mir-194-5p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-124-1/Upstream/839397; hsa-mir-10400/Downstream/1421624;
Nearest TSS
ENST00000518652/Upstream/5275; ENST00000603284/Downstream/858854;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/136955, chr8-CpG: 59/Downstream/1136876
Upstream sequence
ttccaaccttggcactactcgcatttggggccagatcattctttgtaagaggttgtcctgtgtataataggatgtttaccaacatccctggccaccaaat
Downstream sequence
AAAAATAGTTTTGTATGAATGTTTCTAAACTAAAACAAATACAGAATAACCTGTAAACCATACCTTCTGGAGTCAGGTGCTCTGTTAAAATTGAAtgtgt
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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