Basic Information
VIS ID
TVIS20002851
Fusion event
HPV-chr8:q24.13 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr8
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
123786825/122774586 (Hg38)
End
123786825/122774586 (Hg38)
Fragile sites / regions
FRA8C ; FRA8E
Nearest miRNA
hsa-mir-12123/Upstream/3449321; hsa-mir-10400/Downstream/441202;
Nearest TSS
ENST00000518652/Upstream/71163; ENST00000607393/Downstream/6174;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1134437, chr8-CpG: 223/Downstream/5544
Nearby gene
CDK5P1(-4268) ; ZHX2(+6763) ;
Nearest cancer related gene
ZHX2(TSG, +6763) ;
Upstream sequence
GCTCTGTCTTCCCTAGGATATCCCCATCATTTCATGCTCATTTCTCAAATCCATAGGCCTCGTAGTCATTTTCTGTGTTATCACAAGGTTGAATGTCAAG
Downstream sequence
ttttaaaggactcatatgattagatcaggcctatccaaataatcttcataatctccatatttcaagggcaagtgatttggcactttaacaacatctgcaa
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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