Basic Information
VIS ID
TVIS20002857
Fusion event
HPV-DIAPH2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chrX
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
96090434/96835435 (Hg38)
End
96090434/96835435 (Hg38)
Location type
Intronic
Target gene
DIAPH2
miRNAs that regulate target gene
hsa-mir-10b-5p ; hsa-mir-17-3p ; hsa-mir-4520-3p ; hsa-mir-4520-2-3p ; hsa-mir-20a-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-4473 ; hsa-mir-4671-3p ; hsa-mir-4778-3p ; hsa-mir-520f-3p ; hsa-mir-302c-3p ; hsa-mir-512-3p ; hsa-mir-641 ; hsa-mir-3617-5p
Nearest miRNA
hsa-let-7f-2/Upstream/1772209; hsa-mir-105-1/Downstream/9804379;
Nearest TSS
ENST00000429181/Upstream/150418; ENST00000373040/Downstream/48473;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/150068, chrX-CpG: 23/Downstream/3103901
Upstream sequence
gctatccagaggatacagctaggacccatggatgatcgctaaaaggaaaacgattgcagcttaacaaaggaaaagctgtccacagtcaaaactttccagc
Downstream sequence
AATATTCTTGGGTTGGATGGAAAATCCTTGTTTGGGATTTTAAAGACCTTTCCAAAAGAGGAGTCAGGGGCATTTTGTAATCAGCTTTCACCTTTCCCTA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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