Basic Information
VIS ID
TVIS20002863
Fusion event
HPV-XRCC6P5 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chrX
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
98979677/99724679 (Hg38)
End
98979677/99724679 (Hg38)
Location type
Intronic
Target gene
XRCC6P5
Nearest miRNA
hsa-let-7f-2/Upstream/4661453; hsa-mir-105-1/Downstream/6915135;
Nearest TSS
ENST00000429181/Upstream/1150804; ENST00000485971/Downstream/571621;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/3039312, chrX-CpG: 23/Downstream/214657
Upstream sequence
TGAGAAAAAATTTCTGATATAGCTTGTAAATTCTGCTAATTGATCCTTTAGTAAATTGACCATTTGGCAAATAGTCTTTTCTGCGACTACATCAAGAGTC
Downstream sequence
ttggctgaatccaccttataccacaatcaaactctcaaggtcatcaaatagaataaaaggaaaaaaaaattccaaagttcagcaatcacaaagattgagg
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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