Basic Information
VIS ID
TVIS20002879
Fusion event
HPV-MYO16 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr13
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
109180439/108528091 (Hg38)
End
109180439/108528091 (Hg38)
Location type
Intronic
Target gene
MYO16
miRNAs that regulate target gene
hsa-mir-4695-3p ; hsa-mir-602 ; hsa-mir-8485 ; hsa-mir-548b-3p ; hsa-mir-3133
Nearest miRNA
hsa-mir-1267/Upstream/996843; hsa-mir-4502/Downstream/1812867;
Nearest TSS
ENST00000623511/Upstream/192643; ENST00000467639/Downstream/68061;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/31420, chr13-CpG: 22/Downstream/599244
Upstream sequence
GTAAACATGTCACTTCAGTGACAGTTCACTCTCTGAAACCTGATTCCATTCATTTTGACACTGGAAAATTGGTAACTACAGGATCTCCAGGCATTTACTG
Downstream sequence
AAACATGAGGAAGTAAGATTATGGAAAATAAGATAAATACAGAAAATAGTGACAGGCATCTACAGAGGTGAAGCTTTAAGCAATTAAGTGGGATGAATGC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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