Basic Information
VIS ID
TVIS20002891
Fusion event
HPV-GEMIN5 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr5
Cytoband
q33.2
Reference genome
GRCh37/hg19
Start
154312117/154932557 (Hg38)
End
154312117/154932557 (Hg38)
Location type
Intronic
Target gene
GEMIN5
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-34a-5p ; hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-1303 ; hsa-mir-877-3p ; hsa-mir-324-5p ; hsa-mir-10a-5p
Nearest miRNA
hsa-mir-10397/Upstream/103017; hsa-mir-103a-1/Downstream/5541845;
Nearest TSS
ENST00000502646/Upstream/841; ENST00000519059/Downstream/5652;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/73755, chr5-CpG: 55/Downstream/5331
Upstream sequence
tgcctgtaatcccagctacttgggaggctgaggcagagaatcacttgaacccaggaggcagaagttgcagtgagctgagattgcaccactgcactcctgc
Downstream sequence
GTTTTTGCAAGGGTGCAGCAACTCTTCTTTTTTCCTTctctgttgcccaggctggagtgcagtggcacaatcaccacttactgcagccttgacttcccag
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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