Basic Information
VIS ID
TVIS20002920
Fusion event
HPV-KLHL29 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr2
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
23777953/23555083 (Hg38)
End
23777953/23555083 (Hg38)
Location type
Intronic
Target gene
KLHL29
miRNAs that regulate target gene
hsa-mir-127-5p
Nearest miRNA
hsa-mir-3125/Upstream/4206578; hsa-mir-10b/Downstream/1773557;
Nearest TSS
ENST00000437798/Upstream/22498; ENST00000288548/Downstream/87309;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/28662, chr2-CpG: 28/Downstream/7096
Upstream sequence
cagtaagtcaggggccatctgtataaacaagtttcttttgagaggaaacctggtcatgggtcagacacttaggcgttaggccacccaccaggataaagaa
Downstream sequence
GGTCCCCTGTGTCGTGGGTATTTATGGAGGATGACCTCCCCCCCCCCCTCAACTTGTGTCTCCCAGTGTCCCTGAGTGAGACCACCCTACAGGATCCTGG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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