Basic Information
VIS ID
TVIS20002935
Fusion event
HPV-GPR149 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr3
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
154113695/154395906 (Hg38)
End
154113695/154395906 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA3D
Target gene
GPR149
Nearest miRNA
hsa-let-7g/Upstream/2829911; hsa-mir-1224/Downstream/4886740;
Nearest TSS
ENST00000440867/Upstream/71409; ENST00000497890/Downstream/33809;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/273315, chr3-CpG: 49/Downstream/32652
Upstream sequence
gcactttacagacgttatctctggttcacatccttctttctaagatgagaaagcagacattaagggacatacctaaagatacacagaagctgtggacaga
Downstream sequence
TTCAATATTTTTCCTGATTCCTTAGGCTCAGATAGAGGAACCAGCAATCAAGAATTATAAATATGCTAATGTGTGTCTAGTTTTGAACCTAAGTCTAAAA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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