VISDB - VIS Detail

Basic Information

VIS ID

TVIS20002936

Fusion event

HPV-PIGG integration

Validated

Detection method

HIVID

Data source

Curated

Sample type

Tumor

Disease

Not given

Quality evaluation

Normal

Reported year

2015

PubMed ID

25581428

Virus Sequence

Virus name

HPV

Subtype

HPV16

Reference genome

NC_001526.2

Host Sequence

Chromosome

chr4

Cytoband

p16.3

Reference genome

GRCh37/hg19

Start

510375/516586 (Hg38)

End

510375/516586 (Hg38)

Location type

Intronic

Target gene

PIGG

miRNAs that regulate target gene

hsa-mir-186-5p ; hsa-let-7b-5p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-378a-5p ; hsa-mir-4313 ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-4680-5p ; hsa-mir-18a-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-3653-5p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-6818-3p ; hsa-mir-106a-3p ; hsa-mir-6879-3p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-3655 ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-1304-3p ; hsa-mir-500b-3p ; hsa-mir-183-5p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-3664-5p ; hsa-mir-5197-5p ; hsa-mir-6836-3p ; hsa-mir-6881-3p ; hsa-mir-4633-5p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-6778-3p ; hsa-mir-3124-3p ; hsa-mir-130b-5p ; hsa-mir-877-3p ; hsa-mir-5193 ; hsa-mir-532-5p ; hsa-mir-606

Nearest miRNA

hsa-mir-571/Upstream/166334; hsa-mir-12113/Downstream/1469798;

Nearest TSS

ENST00000502981/Upstream/516; ENST00000507493/Downstream/4465;

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/16996, chr4-CpG: 31/Downstream/18791

Upstream sequence

ATAACCTAGGAGACAGTGTTTGAAGAACACAAACTCTAAAGTCCTTCACTTAAAAAAAAAAAAAAACTTTCCCAAATTGCTTACCATTTGGAAAAATTGC

Downstream sequence

gtggctcacgcctgtaatcccagcactttgggaggccaaggcaggcggatcatgaagtcaggaattgaagaccagcctgactaacacagtgaaaccccgt

Reference

Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.