Basic Information
VIS ID
TVIS20002938
Fusion event
HPV-SYNPO2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr4
Cytoband
q26
Reference genome
GRCh37/hg19
Start
119954434/119033279 (Hg38)
End
119954434/119033279 (Hg38)
Location type
Intronic
Target gene
SYNPO2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-150-5p ; hsa-mir-144-5p
Nearest miRNA
hsa-mir-12113/Upstream/4376425; hsa-mir-1305/Downstream/6473980;
Nearest TSS
ENST00000502981/Upstream/9808; ENST00000307128/Downstream/102505;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/196623, chr4-CpG: 67/Downstream/179130
Nearest cancer related gene
SYNPO2(TSG, No orient, 0)
Upstream sequence
TAAAAAAAAAAAAAAACTTTCCCAAATTGCTTACCATTTGGAAAAATTGCCTTACCTTCTTCAGTCATCTCTGATGTTGTCATCCTCAGAGTAAGAAGTA
Downstream sequence
CTTCTCCCACGTTCCTTGCAATTCTATTCTCTCACCTTCACTTTACTATTTGTATTCGATGGACCAGGATAATTCAGGCAAGGTTACCTTGTAAACTTTA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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