Basic Information
VIS ID
TVIS20002944
Fusion event
HPV-MGC4859 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr7
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
10813999/10774372 (Hg38)
End
10813999/10774372 (Hg38)
Location type
Intronic
Target gene
MGC4859
Nearest miRNA
hsa-mir-339/Upstream/3707327; hsa-mir-10399/Downstream/7352848;
Nearest TSS
ENST00000635602/Upstream/71696; ENST00000604183/Downstream/5572;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1047786, chr7-CpG: 31/Downstream/5306
Upstream sequence
TCTCCCTCCCCCCATCTTGTTTAACTTACTTTTTAAAAATGTGTTTTTAAAGTTTGTTTTATAAATTTCATTTCAAGGAATATTAGCAATGAGGCCTTGT
Downstream sequence
TGGGAGAAGAGGACAAGAAGACTGGGTAGGGGCAGTGAATAATCTACTCCAATGGAAGCCCCATTTGAGCTCTTTCGACCAGAAACTTTTGCATCTGAGA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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