Basic Information
VIS ID
TVIS20002959
Fusion event
HPV-PPP1R12B integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;EU918767.1
Host Sequence
Chromosome
chr1
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
202482211/202513083 (Hg38)
End
202482211/202513083 (Hg38)
Location type
Intronic
Target gene
PPP1R12B
miRNAs that regulate target gene
hsa-mir-30b-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-29a-5p ; hsa-mir-659-3p ; hsa-mir-92a-1-5p ; hsa-mir-1228-3p ; hsa-mir-1273h-5p ; hsa-mir-149-3p ; hsa-mir-188-5p ; hsa-mir-2114-3p ; hsa-mir-30b-3p ; hsa-mir-3160-3p ; hsa-mir-3192-5p ; hsa-mir-3689a-3p ; hsa-mir-3689b-3p ; hsa-mir-3689c ; hsa-mir-3689d ; hsa-mir-377-5p ; hsa-mir-4487 ; hsa-mir-455-3p ; hsa-mir-4661-3p ; hsa-mir-4728-5p ; hsa-mir-4780 ; hsa-mir-558 ; hsa-mir-6086 ; hsa-mir-6134 ; hsa-mir-623 ; hsa-mir-6499-3p ; hsa-mir-6516-5p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-6780b-3p ; hsa-mir-6785-5p ; hsa-mir-6799-5p ; hsa-mir-6807-5p ; hsa-mir-6823-3p ; hsa-mir-6851-5p ; hsa-mir-6866-3p ; hsa-mir-6880-5p ; hsa-mir-6883-5p ; hsa-mir-7106-5p ; hsa-mir-7847-3p
Nearest miRNA
hsa-mir-101-1/Upstream/509847; hsa-mir-1182/Downstream/2935219;
Nearest TSS
ENST00000473358/Upstream/16264; ENST00000367269/Downstream/26757;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/164015, chr1-CpG: 104/Downstream/129457
Upstream sequence
GATAAAGCCCACAGCCCCCAGATTCCCTTCTGAAATAGCCCTAGGTCTTTAGATAAAGAGAATCTGGATTGCTCTACTAAGTAAGAACCCCAGGCCTCCC
Downstream sequence
CAGGCACAAGCTGAACAGGAGGGAAACAAGGATGGGTAGAGTGGAGGGAGGTGTTGACTGTCAGTTACAACCTGGGGACTACCTGTAATAGAGGAGACTG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate