Basic Information
VIS ID
TVIS20002963
Fusion event
HPV-TIPIN integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;EU918767.1
Host Sequence
Chromosome
chr15
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
66642851/66350513 (Hg38)
End
66642851/66350513 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA15A
Target gene
TIPIN
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-1273e ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-6807-5p ; hsa-mir-506-3p ; hsa-mir-124-3p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-6499-3p ; hsa-mir-4722-5p ; hsa-mir-2467-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-1827 ; hsa-mir-1233-3p ; hsa-mir-1225-3p ; hsa-mir-219b-3p ; hsa-mir-6840-3p ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-4257 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-4695-5p ; hsa-mir-302f ; hsa-mir-3910 ; hsa-mir-3714 ; hsa-mir-548s ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-1227-3p ; hsa-mir-3926 ; hsa-mir-4252 ; hsa-mir-6889-3p ; hsa-mir-3190-5p ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-6849-3p ; hsa-mir-1273g-3p ; hsa-mir-508-5p ; hsa-mir-3975 ; hsa-mir-6746-5p ; hsa-mir-6771-5p ; hsa-mir-20b-3p ; hsa-mir-2114-5p ; hsa-mir-5588-3p ; hsa-mir-7977 ; hsa-mir-891a-3p
Nearest miRNA
hsa-mir-10393/Upstream/310181; hsa-mir-11181/Downstream/146445;
Nearest TSS
ENST00000557528/Upstream/18810; ENST00000425818/Downstream/6172;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/56357, chr15-CpG: 36/Downstream/5933
Upstream sequence
AAAAACAAGAGAAGTACATTGAAGATGGTATTACAAACTCCTTGCTAGACAAGGGTAAGATGAGAGCCAACTCAAGAGATATAGTTGGGAGAACCATAGA
Downstream sequence
agaatcgcttgaacccaagcggcggaggttgcagtgagccaaggtcgagccattgcactccagcctgggtgacaagggcaaaacttcatctcaaaaaaac
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate