Basic Information
VIS ID
TVIS20002996
Fusion event
HPV-TAF1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;EU918767.1
Host Sequence
Chromosome
chrX
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
70749419/71529569 (Hg38)
End
70749419/71529569 (Hg38)
Location type
Intronic
Target gene
TAF1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-7-5p ; hsa-mir-21-5p ; hsa-mir-4508 ; hsa-mir-7977 ; hsa-mir-3178 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-4486 ; hsa-mir-383-3p ; hsa-mir-6842-3p ; hsa-mir-647 ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-4430 ; hsa-mir-3652
Nearest miRNA
hsa-let-7f-2/Upstream/1506646; hsa-mir-105-1/Downstream/2688808;
Nearest TSS
ENST00000429181/Upstream/37257; ENST00000472270/Downstream/3514;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/36598, chrX-CpG: 32/Downstream/3219
Nearest cancer related gene
TAF1(OG, No orient, 0)
Upstream sequence
gatagataccaggatgttaacagttaacagtggtcatttctgggtagtgagattatgaatgacttttgttccctttatacttttctgagtgctctgaaaa
Downstream sequence
TAAAGCCTCTCATCTAAAGGCATAGAATACTGAATATAGTCTTGAGGCATAAGTCCAATAAGTACAGGCACATGTTCCTTGAAGTGAAGATGCAAGTCTC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate