Basic Information
VIS ID
TVIS20002997
Fusion event
HPV-AGBL4 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr1
Cytoband
p33
Reference genome
GRCh37/hg19
Start
49347898/48882226 (Hg38)
End
49347898/48882226 (Hg38)
Location type
Intronic
Target gene
AGBL4
Nearest miRNA
hsa-mir-12136/Upstream/4336674; hsa-mir-101-1/Downstream/2177611;
Nearest TSS
ENST00000473358/Upstream/105257; ENST00000456002/Downstream/143369;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/105088, chr1-CpG: 34/Downstream/16656
Upstream sequence
taagacaattgtgcatatccgtgattataataatcgtaaactcagatgtactatcagattaaataatttaatttccctaaagtctcatcacagagtgatt
Downstream sequence
ggcacatagtaaatgtacaacaaaATCCAAAAATACTCAAAAAGTTTATTGGTATTAATGCTGCCCACCATCCCAATGAAAAATAATCATCTACGTTTAG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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