Basic Information
VIS ID
TVIS20003031
Fusion event
HPV-NUP93 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr16
Cytoband
q13
Reference genome
GRCh37/hg19
Start
56782927/56749015 (Hg38)
End
56782927/56749015 (Hg38)
Location type
Intronic
Target gene
NUP93
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-125b-5p ; hsa-mir-3149 ; hsa-mir-4715-3p ; hsa-mir-4763-5p ; hsa-mir-29a-5p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-6872-3p ; hsa-let-7c-3p ; hsa-mir-4266 ; hsa-mir-3177-5p ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-6747-5p ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-3922-5p ; hsa-mir-1914-3p ; hsa-mir-6782-5p ; hsa-mir-4779 ; hsa-mir-4695-5p ; hsa-mir-4274 ; hsa-mir-624-3p ; hsa-mir-6839-3p ; hsa-mir-4507 ; hsa-mir-3940-5p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-6781-3p ; hsa-mir-2682-3p ; hsa-mir-6774-5p ; hsa-mir-635 ; hsa-mir-4772-3p ; hsa-mir-4638-5p ; hsa-mir-1304-3p ; hsa-mir-6741-3p ; hsa-mir-4485-5p ; hsa-mir-6890-3p ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-7703 ; hsa-mir-6807-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-193b-5p ; hsa-mir-4252 ; hsa-mir-7155-5p ; hsa-mir-4793-3p ; hsa-mir-1273g-3p ; hsa-mir-4438 ; hsa-mir-128-3p ; hsa-mir-216a-3p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-3681-3p ; hsa-mir-6081 ; hsa-mir-6750-3p
Nearest miRNA
hsa-mir-1225/Upstream/503392; hsa-mir-11401/Downstream/109503;
Nearest TSS
ENST00000527434/Upstream/666; ENST00000567081/Downstream/32643;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/18450, chr16-CpG: 80/Downstream/182807
Upstream sequence
AAACCATCCAAGTGAGGAGTGATTCTGTCTGCTTGTTGTCAGTGACCCGGGAGGCTGCTTCTGAAAGGCCTTGGAAATACAGTGCCCCCAGCTGATTGTA
Downstream sequence
GGGAAAAGTGCTGACTGACTGAGCTGGCAGCCACTGCTGCCACACAGCATCAGTTGGGCTGttgattccacaaacgtgtttaaggtccacgctgtgccag
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate