Basic Information
VIS ID
TVIS20003061
Fusion event
HPV-ADCY2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr5
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
7553400/7553287 (Hg38)
End
7553400/7553287 (Hg38)
Location type
Intronic
Target gene
ADCY2
miRNAs that regulate target gene
hsa-mir-6833-5p ; hsa-mir-3190-3p ; hsa-mir-4680-5p ; hsa-mir-7114-5p ; hsa-mir-4539 ; hsa-mir-146a-3p ; hsa-mir-4714-5p ; hsa-mir-4318 ; hsa-mir-4643 ; hsa-mir-5698 ; hsa-mir-143-5p ; hsa-mir-6879-3p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-500b-3p ; hsa-mir-3922-5p
Nearest miRNA
hsa-mir-4277/Upstream/725366; hsa-mir-10397/Downstream/907638;
Nearest TSS
ENST00000502646/Upstream/138623; ENST00000513693/Downstream/57822;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/156740, chr5-CpG: 112/Downstream/296545
Upstream sequence
cccaggaggcggaagttacagtgagccaagattgcaccactgcactccagcctgggtgacagaggaagaaaccctctcaaataaataaataaaTGTGATA
Downstream sequence
tacatgtgaGGTTAACCACAGTGGCGTTCACTGCAGTCTTCGGAGGAGCGCAGTTCTGAAGGCTGCTGGCCTTTGACCTGGCCCTGTGGAAGGCCCTTCC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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