Basic Information
VIS ID
TVIS20003090
Fusion event
HPV-DNAJC6 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37/hg19
Start
65747067/65281384 (Hg38)
End
65747067/65281384 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
DNAJC6
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-let-7c-5p ; hsa-let-7a-5p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-4260 ; hsa-mir-1227-5p ; hsa-mir-3147 ; hsa-mir-4425 ; hsa-mir-6867-5p ; hsa-mir-486-3p ; hsa-mir-6721-5p
Nearest miRNA
hsa-mir-101-1/Upstream/222876; hsa-mir-11399/Downstream/1347056;
Nearest TSS
ENST00000473358/Upstream/16620; ENST00000472787/Downstream/25137;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/15218, chr1-CpG: 74/Downstream/27949
Upstream sequence
tggcattaagcgcattcatgtggttgtgcagccatcaccatcacccatctccagagcttcttcatgttccaaacctgacaatctgtccccatgacacacc
Downstream sequence
aatccccttaccccgacccgagcccttgaacccccattctaccctctgtctccatgtgtatgaatcctctggggacctcacaggagtggaatcagtcttt
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate