Basic Information
VIS ID
TVIS20003109
Fusion event
HPV-TRPM1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr15
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
31376721/31084518 (Hg38)
End
31376721/31084518 (Hg38)
Location type
Intronic
Target gene
TRPM1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-619-5p ; hsa-mir-6807-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-4252 ; hsa-mir-4438 ; hsa-mir-6889-3p
Nearest miRNA
hsa-mir-1268a/Upstream/19377; hsa-mir-10393/Downstream/3297551;
Nearest TSS
ENST00000557528/Upstream/16426; ENST00000559292/Downstream/17188;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/58189, chr15-CpG: 67/Downstream/131085
Upstream sequence
ggccaacatggtgataccccatctctaccaaaaatacaaaaattagttgggcgtggtggtgggcacttgcaatcccagctacttgggaggctgaagcagt
Downstream sequence
aggtagcgcagatcaggactttactcttttctatgcctctgtaatattccattacatgaattcatcagttgatgaatttgggttgtttccacttttggct
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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