Basic Information
VIS ID
TVIS20003122
Fusion event
HPV-SLC39A10 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr2
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
196527955/195663231 (Hg38)
End
196527955/195663231 (Hg38)
Location type
Intronic
Target gene
SLC39A10
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-186-5p ; hsa-mir-140-3p ; hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-324-5p ; hsa-mir-221-5p ; hsa-mir-3128 ; hsa-mir-3646 ; hsa-mir-4720-5p ; hsa-mir-4799-3p ; hsa-mir-5588-5p ; hsa-mir-8073 ; hsa-mir-218-5p ; hsa-mir-582-5p ; hsa-mir-591 ; hsa-mir-6502-3p ; hsa-mir-7851-3p ; hsa-mir-619-3p ; hsa-mir-1252-3p ; hsa-mir-623 ; hsa-mir-7106-3p ; hsa-mir-5689 ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-6780b-3p ; hsa-mir-4780
Nearest miRNA
hsa-mir-10b/Upstream/6530120; hsa-mir-1244-1/Downstream/11120003;
Nearest TSS
ENST00000437798/Upstream/5782; ENST00000465851/Downstream/17246;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/5005, chr2-CpG: 34/Downstream/405355
Upstream sequence
TGCAACAACGAGGCCAGTGTAGAAGGAGAATAAAGAAACTGGTGCATTTGGAGTCAGACAAAAAGTTCATTCATGGCTCTTTCAGTCTGGAAGATTCTGA
Downstream sequence
CACTCCCCTCATAAAGCAATTCAAAACTGCATGCTTACAGGCCTTTAAACAAATATTTTGGTATATTAACTCAGTGCACTTCTACTGAAGATGACTCCTT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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