Basic Information
VIS ID
TVIS20003123
Fusion event
HPV-NDUFS1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr2
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
206999405/206134681 (Hg38)
End
206999405/206134681 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2I
Target gene
NDUFS1
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-324-5p ; hsa-mir-221-3p ; hsa-mir-3682-5p ; hsa-mir-218-5p ; hsa-mir-3915 ; hsa-mir-5093 ; hsa-mir-3928-3p ; hsa-mir-4670-3p ; hsa-mir-4330 ; hsa-mir-3688-3p ; hsa-mir-1252-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-5011-5p ; hsa-mir-5580-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-4279 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-4428 ; hsa-mir-493-5p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-let-7c-3p ; hsa-mir-5701 ; hsa-mir-552-5p ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-1-3p ; hsa-mir-206 ; hsa-mir-3652 ; hsa-mir-4430 ; hsa-mir-5693 ; hsa-mir-6128 ; hsa-mir-613 ; hsa-mir-6722-5p ; hsa-mir-7151-3p
Nearest miRNA
hsa-mir-10b/Upstream/17001570; hsa-mir-1244-1/Downstream/648553;
Nearest TSS
ENST00000437798/Upstream/1712; ENST00000479587/Downstream/24513;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/48877, chr2-CpG: 94/Downstream/24505
Upstream sequence
ATTTGGAGTCAGACAAAAAGTTCATTCATGGCTCTTTCAGTCTGGAAGATTCTGAAACTTTGGTAACATAGTAATTCCTAAATAAGAATAAGGCAAGTGG
Downstream sequence
ACAGATATGAAAAAccaggcaaggttggctcatgcttgtaatcccaacactttagaaggctgaggtgggagaattgcttgaggccaggagtttgaggcca
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate