Basic Information
VIS ID
TVIS20003124
Fusion event
HPV-XRCC5 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr2
Cytoband
q35
Reference genome
GRCh37/hg19
Start
217047312/216182589 (Hg38)
End
217047312/216182589 (Hg38)
Location type
Intronic
Target gene
XRCC5
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-331-3p ; hsa-mir-7-5p ; hsa-mir-100-5p ; hsa-mir-26b-5p ; hsa-mir-7977 ; hsa-mir-4528 ; hsa-mir-584-5p ; hsa-mir-758-5p ; hsa-mir-218-2-3p ; hsa-mir-29b-1-5p ; hsa-mir-361-5p ; hsa-mir-92a-2-5p ; hsa-mir-3927-5p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-1324 ; hsa-mir-2115-3p ; hsa-mir-31-5p ; hsa-mir-526b-5p ; hsa-mir-623
Nearest miRNA
hsa-mir-10b/Upstream/2424430; hsa-mir-1244-1/Downstream/1717924;
Nearest TSS
ENST00000437798/Upstream/51879; ENST00000485763/Downstream/21427;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/73048, chr2-CpG: 85/Downstream/188713
Nearest cancer related gene
XRCC5(TSG, No orient, 0)
Upstream sequence
TTCATTCATGGCTCTTTCAGTCTGGAAGATTCTGAAACTTTGGTAACATAGTAATTCCTAAATAAGAATAAGGCAAGTGGATTTTAATAAAGGGCAATAC
Downstream sequence
CCACCACAACACATTCTTTCAGGCATATGGCATATATATTTCCTAAAAAGCTGAAAGATATCATTTCCTCATTTAATTAGAAAGTCTTCCTTTAGTTTCT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate