Basic Information
VIS ID
TVIS20003136
Fusion event
HPV-TLR2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr4
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
154608749/153687597 (Hg38)
End
154608749/153687597 (Hg38)
Location type
Intronic
Target gene
TLR2
miRNAs that regulate target gene
hsa-mir-146a-5p ; hsa-mir-105-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-335-5p ; hsa-mir-106b-5p ; hsa-mir-154-5p ; hsa-mir-101-5p ; hsa-mir-143-3p ; hsa-mir-23a-5p
Nearest miRNA
hsa-mir-12113/Upstream/1151081; hsa-mir-1305/Downstream/5441205;
Nearest TSS
ENST00000502981/Upstream/3307; ENST00000643087/Downstream/13903;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/2697, chr4-CpG: 60/Downstream/72025
Upstream sequence
ctccctccaccgtctagtagtccacagtgtctattgtgtctcatatttatgtccatacatgctcaatgcttagcttccatttataagtgagaatatgtgg
Downstream sequence
tttttttttgtaattaatagctaaatttccaccaaatcataaatagccaagctttagccaatcacaggcagccaactgatcagactatgcccaaacaagg
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate