Basic Information
VIS ID
TVIS20003140
Fusion event
HPV-ZFAND3 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
38007911/38040135 (Hg38)
End
38007911/38040135 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
ZFAND3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6731-3p ; hsa-mir-770-5p ; hsa-mir-4712-5p ; hsa-mir-7844-5p ; hsa-mir-3199 ; hsa-mir-365a-5p ; hsa-mir-365b-5p ; hsa-mir-4521 ; hsa-mir-4709-3p ; hsa-mir-488-3p ; hsa-mir-541-5p ; hsa-mir-5681a ; hsa-mir-6730-5p ; hsa-mir-6768-3p ; hsa-mir-7854-3p ; hsa-mir-8052
Nearest miRNA
hsa-mir-1236/Upstream/484713; hsa-mir-10398/Downstream/1034179;
Nearest TSS
ENST00000381078/Upstream/110176; ENST00000469208/Downstream/21476;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/220361, chr6-CpG: 77/Downstream/599294
Upstream sequence
aggagttcaagaccagcctggccaacatggtgaagccccgactctactaaaaatacaaaaaaattagctgggcctgggggtgagtgcctataatctcagc
Downstream sequence
GTCTGTATGTAGATACCTGCCTCAGCTCTTAAAGGACCTTCTGGTTGTTAACACTTACAGAAAAGGTTGTAGTGACTATTCTTGCATACACATCttttaa
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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