Basic Information
VIS ID
TVIS20003158
Fusion event
HPV-NLGN4X integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chrX
Cytoband
p22.32
Reference genome
GRCh37/hg19
Start
5968429/6050388 (Hg38)
End
5968429/6050388 (Hg38)
Location type
Intronic
Target gene
NLGN4X
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-26b-5p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-4666b ; hsa-mir-5011-3p ; hsa-mir-502-3p ; hsa-mir-501-3p ; hsa-mir-6718-5p ; hsa-mir-203b-5p ; hsa-mir-6507-5p ; hsa-mir-574-5p ; hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-5011-5p ; hsa-mir-6501-3p ; hsa-mir-4797-5p ; hsa-mir-6128 ; hsa-mir-1324 ; hsa-mir-6504-3p ; hsa-mir-1243 ; hsa-mir-3654 ; hsa-mir-323a-3p ; hsa-mir-429 ; hsa-mir-200c-3p ; hsa-mir-200b-3p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-23b-3p ; hsa-mir-23a-3p ; hsa-mir-130a-5p ; hsa-mir-23c ; hsa-mir-6831-3p ; hsa-mir-8066 ; hsa-mir-550b-3p ; hsa-mir-6758-3p ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-5003-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-139-3p ; hsa-mir-942-5p ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-1248 ; hsa-mir-1237-3p
Nearest miRNA
hsa-mir-3690-1/Upstream/3441134; hsa-let-7f-2/Downstream/333518;
Nearest TSS
ENST00000429181/Upstream/147035; ENST00000217961/Downstream/101078;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/146730, chrX-CpG: 138/Downstream/175691
Upstream sequence
GAAAACTATTTCTCAAAAAAAGCTATGCTAAGATTGCTAATTGGGAGAGGTTATGCCCTTTCTGTCCACCTTGTGTTCATTATTTCAGTTACAGCAAGCA
Downstream sequence
tatttacctatctacctgtctattcatctctatctaaatttatatctacttatttacctacctatctatccatctctatcatctatccatctCTAACATC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate