Basic Information
VIS ID
TVIS20003265
Fusion event
HPV-RPL6 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr12
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
112856620/112418816 (Hg38)
End
112856620/112418816 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA12E ; FRA12D
Target gene
RPL6
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-16-5p
Nearest miRNA
hsa-let-7i/Upstream/255495; hsa-mir-1178/Downstream/276218;
Nearest TSS
ENST00000382841/Upstream/465; ENST00000639857/Downstream/22;
Nearest CpG islands
chr12-CpG: 86/Target, None/Upstream, None/Downstream
Upstream sequence
ACACATGTTCTGCATCAATCCACGTTGGCTGAGCAGTGAGAAGGCAGCATGTTACAGTCTTGCCTCTCCACAGACGTTGGTGGCATCTTTCTTCCCTGCC
Downstream sequence
CGTGTCTTTATGGCTGCTCGGTTTTCCTCTGCTGTCAGCTCTCCCGGCCTCTGTTGAATGGCCTGCACTTAGTTTTAGTCGATTTCCTCCCCTGAGTCTG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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