Basic Information
VIS ID
TVIS20003273
Fusion event
HPV-LHX4 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr1
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
180237264/180268129 (Hg38)
End
180237264/180268129 (Hg38)
Location type
Intronic
Target gene
LHX4
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-4313 ; hsa-mir-3605-5p ; hsa-mir-6832-3p ; hsa-mir-6894-5p ; hsa-mir-548s ; hsa-mir-3688-5p ; hsa-mir-3926 ; hsa-mir-4470 ; hsa-mir-4786-5p ; hsa-mir-3190-5p ; hsa-mir-6849-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-548as-3p
Nearest miRNA
hsa-mir-101-1/Upstream/464104; hsa-mir-1182/Downstream/170185;
Nearest TSS
ENST00000473358/Upstream/19844; ENST00000442621/Downstream/6552;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/32289, chr1-CpG: 92/Downstream/234061
Nearest cancer related gene
LHX4(TSG, No orient, 0)
Upstream sequence
ataattcacataccataaaattcaccttttcaaagtgtacaactcagtggtttttagtatattcataaggttgtacagtcatcactactatctaattcca
Downstream sequence
taacgctttcatggaaaccattaatagtcgctccccttttcctcctccccctagcccctggcaaccactaatctatttgtccctgcggatttgcctattc
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate