Basic Information
VIS ID
TVIS20003274
Fusion event
HPV-ATP2B4 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr1
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
203604251/203635123 (Hg38)
End
203604251/203635123 (Hg38)
Location type
Intronic
Target gene
ATP2B4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1-3p ; hsa-mir-21-5p ; hsa-mir-423-5p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-1277-5p ; hsa-mir-5011-5p ; hsa-mir-190a-3p ; hsa-mir-218-5p ; hsa-mir-6806-5p ; hsa-mir-4290 ; hsa-mir-488-5p ; hsa-mir-4747-3p ; hsa-mir-6083 ; hsa-mir-642a-5p ; hsa-mir-452-3p ; hsa-mir-7106-3p ; hsa-mir-6886-3p ; hsa-mir-938 ; hsa-mir-18a-3p ; hsa-mir-7113-3p ; hsa-mir-6734-3p ; hsa-mir-6891-3p ; hsa-mir-6072 ; hsa-mir-6752-3p
Nearest miRNA
hsa-mir-101-1/Upstream/1631887; hsa-mir-1182/Downstream/1813179;
Nearest TSS
ENST00000473358/Upstream/8336; ENST00000466407/Downstream/47686;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/5398, chr1-CpG: 57/Downstream/160317
Upstream sequence
tgtatgtatgagaaatattgctgttttaaaatattggaatcatattatatactcttctatgcatcgcacttaacaatacatcatgaaataactgagtcag
Downstream sequence
ccaaactagatataataaattcttttaaacaattgcataatattccatgaaatggctaacctataacttactcaatcattcctttagaaatgagtattca
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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