Basic Information
VIS ID
TVIS20003281
Fusion event
HPV-chr21:q21.2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr21
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
25057294/23684977 (Hg38)
End
25057294/23684977 (Hg38)
Nearest miRNA
hsa-let-7c/Upstream/605585; hsa-mir-155/Downstream/1889003;
Nearest TSS
ENST00000624081/Upstream/207336; ENST00000415269/Downstream/205564;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/2686732, chr21-CpG: 28/Downstream/1676817
Upstream sequence
ACGTAGATGCATGACTTTATATTTATGGAGATTTTATATACATTCATCAtgtctctgtagctagattgaaagctccttaagggctagaaccaagtattcc
Downstream sequence
gctttacatTTATTTTGCAAGCTGGAATAGCCTCTATTCATTTTTTAAGACAGTCCTCAGAATTCACTTCCTTCCCCTACAGGTCTGAGAGAGCCATCGC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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