Basic Information
VIS ID
TVIS20003296
Fusion event
HPV-MASP2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr1
Cytoband
p36.22
Reference genome
GRCh37/hg19
Start
11100541/11040484 (Hg38)
End
11100541/11040484 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
MASP2
Nearest miRNA
hsa-mir-12136/Upstream/1073026; hsa-mir-101-1/Downstream/988674;
Nearest TSS
ENST00000473358/Upstream/10726; ENST00000452378/Downstream/2714;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/27296, chr1-CpG: 146/Downstream/18489
Upstream sequence
gaatgagtttgtctggccccagattcctcttctatgaatgaagaaatttcaaatgacttctcatctctacaatctataacaCAGCTATTTCAGCAGTAGC
Downstream sequence
TGTCTCTTACCTTTGTATGAATAGGAAGCAATTGTATTTTTCTTACAAATTTCTTCTTCAAATTATTCATTTGTTGGTTCATTTAATTTAATTATCTCCC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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