Basic Information
VIS ID
TVIS20003327
Fusion event
HPV-DPP4 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr2
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
162930970/162074460 (Hg38)
End
162930970/162074460 (Hg38)
Location type
Intronic
Target gene
DPP4
Nearest miRNA
hsa-mir-128-1/Upstream/1666578; hsa-mir-10b/Downstream/6508483;
Nearest TSS
ENST00000437798/Upstream/338; ENST00000432251/Downstream/82;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/91, chr2-CpG: 44/Downstream/269605
Nearest cancer related gene
DPP4(TSG, No orient, 0)
Upstream sequence
taaaataatcatgatgaatatgctaagtgctctagtggaaaatgttgacaacatgcaaaaacacaggtaatctaagtagagagatctaagaaagaaatgc
Downstream sequence
gcaggggactttggcaaactcacacagcccaccgcaggcaactggaactgaaacccaggactccgtctcttgccagtGAAAGTTATGTTAGGAAGCAGTG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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