Basic Information
VIS ID
TVIS20003332
Fusion event
HPV-NPAS3 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
HE574705.1;NC_001526.2;AY262282.1;HQ537777.1;EU918767.1
Host Sequence
Chromosome
chr14
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
33490308/33021102 (Hg38)
End
33490308/33021102 (Hg38)
Location type
Intronic
Target gene
NPAS3
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-mir-3679-3p ; hsa-mir-4446-5p ; hsa-mir-361-3p ; hsa-mir-153-5p ; hsa-mir-589-3p ; hsa-mir-548as-3p ; hsa-mir-143-5p ; hsa-mir-2681-5p ; hsa-mir-3944-5p ; hsa-mir-8066
Nearest miRNA
hsa-mir-208a/Upstream/2006360; hsa-mir-1185-1/Downstream/3931207;
Nearest TSS
ENST00000550708/Upstream/81785; ENST00000549770/Downstream/192576;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/81073, chr14-CpG: 152/Downstream/778638
Upstream sequence
TATGATGACACCCACCTTATAGGATTTTAATAGGATTAAACAAACAAAAAAAAACAAGTATACACTCCTCAAAAACCACTAGCAATTATTAGTATTAAAA
Downstream sequence
CCACTGCCTCCAATTTGTTGATAAGTGGcttgaagggttatcgtgagaagtagaggatgttgcttatggaaagtgccttgcagagggcctggtacTGGAT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate