Basic Information
VIS ID
TVIS20003337
Fusion event
HPV-NPAS2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
HE574705.1;NC_001526.2;AY262282.1;HQ537777.1;EU918767.1
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
101587451/100970989 (Hg38)
End
101587451/100970989 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2A
Target gene
NPAS2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-484 ; hsa-mir-17-5p ; hsa-mir-93-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/4172636; hsa-mir-10b/Downstream/338461;
Nearest TSS
ENST00000437798/Upstream/388; ENST00000471974/Downstream/3814;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/149998, chr2-CpG: 39/Downstream/30796
Nearest cancer related gene
NPAS2(TSG, No orient, 0)
Upstream sequence
tctagtggaaaatgttgacaacatgcaaaaacacaggtaatctaagtagagagatctaagaaagaaatgctagaaatcaaaaacactgcaacaaacaaag
Downstream sequence
TTACGCAGATGTCCGGGTGGAAAGGAGGCAGGAGCTGGCTCTGGAAGACCCGCCATCCGAGGCCCTCCACTCCTCAGCACTAAAGGTACGCCCATCCCTG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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