Basic Information
VIS ID
TVIS20003341
Fusion event
HPV-ARHGEF2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537688.1;HQ537777.1
Host Sequence
Chromosome
chr1
Cytoband
q22
Reference genome
GRCh37/hg19
Start
155937984/155968193 (Hg38)
End
155937984/155968193 (Hg38)
Location type
Intronic
Target gene
ARHGEF2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-96-5p ; hsa-mir-877-3p ; hsa-mir-744-5p ; hsa-mir-423-3p ; hsa-mir-320a ; hsa-mir-4728-5p ; hsa-mir-328-3p ; hsa-mir-6734-5p ; hsa-mir-1226-5p ; hsa-mir-6834-5p ; hsa-mir-3175 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-6851-3p ; hsa-mir-6775-3p ; hsa-mir-1291 ; hsa-mir-6799-3p ; hsa-mir-3173-5p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-7845-5p ; hsa-mir-942-3p ; hsa-mir-4475 ; hsa-mir-194-3p
Nearest miRNA
hsa-mir-101-1/Upstream/16857; hsa-mir-1182/Downstream/452148;
Nearest TSS
ENST00000473358/Upstream/1714; ENST00000610146/Downstream/1536;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/17086, chr1-CpG: 87/Downstream/9694
Nearest cancer related gene
ARHGEF2(OG, No orient, 0)
Upstream sequence
CAAGACTCCCATCTAAAGTTTTTCCCCTGCCTGACCATTTTATTGGTGGCTGAAGGATTCTAGAGAACCTGTTGTTCTTGTAAGGAAAACAAGAAGCCaa
Downstream sequence
aaaaaaaaaaaaaattaaaaCGGCAGATTCAGCAAGCTGCTGTGGGGAGGTGTTAAGGGCAGCTGTTTGGGGGATCGCACATAACACCACATGGCTAGAA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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