Basic Information
VIS ID
TVIS20003363
Fusion event
HPV-ZNF530 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr19
Cytoband
q13.43
Reference genome
GRCh37/hg19
Start
58115891/57604523 (Hg38)
End
58115891/57604523 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
ZNF530
Nearest miRNA
hsa-let-7e/Upstream/2216281; hsa-mir-10394/Downstream/730165;
Nearest TSS
ENST00000633603/Upstream/4620; ENST00000598297/Downstream/132;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/4121, chr19-CpG: 46/Downstream/9639
Upstream sequence
tatctccttggcacatttcttactcatactctaaatttatttatttatttttatattggttttcagatttctcttgcatctctttgtattggggaaaccc
Downstream sequence
TTGGCATATGTATTCTGAGGGACATCGCCAAGCAAGGCACTCTCAGACTGTCCTAACACCTGTTTCCTCTAGGTATGCAGTGAAGGGTCTGGGAGACAGG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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